Cutaneous Dermal Ia+ Cells Are Capable of Initiating Delayed Type Hypersensitivity Responses
نویسندگان
چکیده
منابع مشابه
Nadroparin carries a potentially high risk of inducing cutaneous delayed-type hypersensitivity responses.
BACKGROUND Heparins are widely used for the prophylaxis/treatment of thromboembolic events. As adverse effects, heparin-induced skin lesions occur frequently (in 7.5-39% of patients). Skin lesions may be the only clinical manifestation of life-threatening immune-mediated heparin-induced thrombocytopenia, but are commonly caused by a delayed-type hypersensitivity response [heparin-induced delaye...
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Delayed-type hypersensitivity (DTH) is a prototypic T lymphocyte-mediated response to antigenic challenge. In this study, mononuclear cells infiltrating the skin during cutaneous response to tuberculin in presensitized human subjects (responders) and nonimmune controls were identified using monoclonal antibodies by indirect immunofluorescence. In both responders and controls the infiltrate cons...
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although recently paradoxical potentiation of antibody titers has been reported (11, 14). Cancer chemotherapists have been concerned for many years that the drugs used in treating cancer might suppress any host immunity to the tumor and actually hasten rather than retard its spread. It was for this reason that the present study was under taken. Briefly, the experimental design consisted of asse...
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BALB/c mice injected intravenously with 10(6) or higher doses of formaldehyde-fixed promastigotes (ffp) of Leishmania major developed significantly lower levels of delayed-type hypersensitivity (DTH) compared with uninjected control mice when they were subsequently immunized intradermally with ffp. The suppression of DTH was antigen specific and was also inducible with lethally irradiated proma...
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ژورنال
عنوان ژورنال: Journal of Investigative Dermatology
سال: 1990
ISSN: 0022-202X
DOI: 10.1111/1523-1747.ep12874114